The Dana-Farber/Boston Children’s Cancer and Blood Disorders Center have seen promising early results in a clinical trial to treat sickle cell disease. The first patient to undergo treatment has not received a blood transfusion in nine months, after receiving monthly blood transfusions for most of his life (1). Sickle Cell Disease Sickle cell disease is [Read More]
Two clinical trials are expected to start soon to assess the ability of stem cells to treat macular degeneration, a leading cause of blindness in people over 50 years old. One trial uses cells derived from human embryonic stem cells, while the other uses induced pluripotent stem cells (1). Macular Degeneration Age-related macular degeneration is [Read More]
Stemedica Cell Technologies are reporting that using ischemic tolerant mesenchymal stem cells (itMSCs) to treat ischemic stroke is safe, well-tolerated, and shows preliminary signs of efficacy in an open-label Phase I/IIa trial. This treatment, which is also being developed for treating Alzheimer’s disease, could begin Phase IIb trials in the near future (1). Ischemic Stroke [Read More]
Does lower back pain stop you from living a life you really love? You deserve to live an active and rewarding life, but degenerative disc disease makes that virtually impossible. By learning more about this lower back disease and its potential treatments, you can get the help you need to embrace life once again. What [Read More]
BrainStorm Cell Therapeutics have received approval from the United States Food and Drug Administration to proceed with Phase 2 trials for their stem cell treatment for progressive multiple sclerosis (1). The treatment utilizes a proprietary autologous stem cell treatment, injecting patient-derived mesenchymal stem cells that secrete neurotrophic factors to stem the advance of disease (2). [Read More]
ViaCyte, headquartered in San Diego, has received funding commitments to continue clinical trials on their beta cell replacement products (1). The products, PEC-Direct and PEC-Encap, contain stem cells that differentiate into pancreatic cells, including insulin-secreting beta cells, after implantation. Additionally, these cells are housed in a capsule that prevents rejection of the implanted cells. If [Read More]
In the developing brain, the subplate is a region of neurons that sits below the cortical plate, a precursor to the cortex. However, in the adult brain it seems to be absent and for decades has been thought to simply disappear. Previous studies had outlined a connection between subplate neurons and certain brain disorders, including [Read More]
A diagnosis of Parkinson’s disease comes with the inherent knowledge that there is no cure for the disease. Treatments are available to slow the progression and control symptoms to an extent, but there is no way to replace the dopaminergic neurons that have already died. Thankfully for patients and their loved ones, clinical trials are [Read More]
Novel approach in mesenchymal stem cell-based therapy for radiation-induced lung injury Current problems in cancer and anticancer therapies are very acute these days. One of the most common cancers for both men and women is the lung cancer, which is by far the leading cause of cancer death each year. The American Cancer Society’s estimates [Read More]
Your neck connects your head and your torso, which means it plays a critical role in the overall function of the upper body and health of your spin. A neck injury can completely disrupt your daily life and obstruct even simple daily tasks. So, how can you seek long-term relief from neck pain without relying [Read More]
The inside surface of the knee joint is lined with a tough articular cartilage that has a slippery texture which allows smooth movement. This cartilage does not have a blood or nerve supply. This means any damage to the articular cartilage cannot be naturally repaired. With age-related wear and tear, the joint gradually degenerates and [Read More]
In a major breakthrough, doctors have developed a new technique to cure age-related macular degeneration (ARMD), the third leading cause of blindness around the world. An 86-year-old patient in the United Kingdom has regained sight in one eye after undergoing the procedure. This pioneering stem cell therapy was performed at a London hospital. Human embryonic [Read More]
Lennart Thy, a 26-year-old German footballer who is on loan from Werder Bremen to the Dutch football club VVV-Venlo, missed an important clash earlier this month to donate stem cells. The young sportsman has been found to be a DNA match for a patient in need of a stem cell transplant. The blood donated by [Read More]
The results of new research indicate that a treatment involving transplantation of stem cells could change the face of multiple sclerosis treatments. The patient’s immune system is first wiped out with anti-cancer medications. Following this, a new immune system is developed with the help of a stem cell transplant. One patient, age 36, says the [Read More]
Scientists are trying to use genetic treatments to save a species of the rhino known as the northern white. After the death of the last remaining male of the species in March 2018, only two females remain. The animals live in Kenya’s Ol Pejeta Reserve but technically belong to the Czech Republic’s Dvr Kralove Zoo. [Read More]
Researchers at Cardiff University’s specialist brain unit have developed an innovative stem cell treatment to slow down the symptoms of Huntington’s disease, a devastating degenerative disorder. The first procedures are expected to take place at the end of 2018. The stem cell transplant will be accomplished through a new type of procedure. The efficacy of [Read More]
From strangers to best friends, a stem cell transplant recipient was asked by the man who saved his life to be his best man. The two men, Brett Dingwall and Paul Rogers, became friends following the transplant. Brett Dingwall was diagnosed with acute myeloid leukemia more than a decade ago. He survived the illness thanks [Read More]
Caroline Wyatt, a 49-year-old journalist with the British Broadcasting Corporation, has spoken about how a pioneering stem cell treatment has helped lift the brain fog associated with her multiple sclerosis. She says she hasn’t felt this good in a long time. Wyatt’s MS was diagnosed after more than two decades of seeing doctors for unexplained [Read More]
An 8-year-old patient with cancer has found a stem cell donor thanks to efforts by pop star Ed Sheeran. The high-profile appeal was also backed by a number of other celebrities. Eight-year-old Jasmi Lindberg-Cooke was diagnosed with acute lymphoblastic leukemia three years ago. The Suffolk resident urgently needed a matched unrelated stem cell donor who [Read More]
Three patients in the United States have lost most of their ability to see after undergoing unregulated stem cell treatments. Stem cell surgery is often the last bastion of hope for people hoping for a restoration of sight. However, the treatments are risky when conducted at unsupervised clinics, such as a private one in Florida [Read More]
The University of Leicester has broken a British charity’s record for the maximum number of registrations for stem cell donors in a single day. The event was promoted by a Rik Basra, a policeman who successfully underwent stem cell transplantation a few years ago. Basra has been encouraging blacks and Asians to register as stem [Read More]
Joel Picker-Spence of Farndon in Nottinghamshire died in 2008 before his seventh birthday. But before he died, he did what most 6-year-olds cannot even dream of. Joel potentially saved the lives of 14 people who would have probably not survived without the stem cell donations collected during the Join for Joel campaign. Although there was [Read More]
A mother from Nuneaton has called for the United Kingdom’s public health services provider NHS to review the decision to end stem cell funding for relapsed patients. Her children Charlie, 5, and Zoe, 3, suffer from a rare genetic disorder and have both undergone stem cell transplants. Charlie’s procedure was successful, but his sister Zoe [Read More]
Twenty-four-year-old fraternal twins, Sean and Ryan Collard from the United Kingdom were diagnosed with testicular cancer within weeks of each other. The two are now raising awareness about the condition which affects young men. Ryan was diagnosed first, and at the time, his mother asked experts whether his twin was at risk and needed to [Read More]
Stem cell scientists are trying to better understand cancer and develop drugs that are essentially “tuneable.” The new project by Scottish researchers is based on a technique developed by Strathclyde University scientists in collaboration with a spinoff company. The idea is to develop drugs which can be customized to the patient’s individual needs. The project [Read More]
A scientist in Hong Kong, Professor Ronald Li, has used stem cells to grow tiny human hearts. These lab-grown miniature organs function exactly like a real human heart. Researchers plan to use them to test new drugs. Professor Li’s stem cell company, Novoheart, is marketing the invention to pharmaceutical companies around the world. These tiny [Read More]
Stem cell research is breaking new ground and making the transition from the lab to the real world. Scientists have succeeded in growing a new trachea from a patient’s stem cells and transplanting it back to replace a diseased windpipe. The breakthrough could hold new hope for patients battling serious medical conditions such as heart [Read More]
When Ava Stark was age 3, her family received devastating news. The toddler was born with a rare blood disorder and would die without a stem cell transplant. The family from Lochgelly in Fife, Scotland, sent out a countrywide appeal for donors after a donor who had previously been found had to back out due [Read More]
A laboratory in Lanarkshire in the United Kingdom has begun harvesting stem cells from the teeth of pediatric patients. The hope is that these harvested cells will be available to cure diseases that the children may develop later in life. Parents who avail this service will pay a monthly fee to BioEden, an American company, [Read More]
Leonarda McCourt, a 77-year-old great grandfather from Newcastle in the United Kingdom participated in the world’s first regulated stem cell study for patients who have suffered a stroke. One of only 21 patients enrolled in the trial, McCourt received a direct injection of stem cells into his brain in 2016. This is a pioneering treatment [Read More]
A new scientific revolution is taking place in China in the field of stem cell research. Unlike the Western world, the laws in China are quite lax with no moral or ethical barriers to hold back research in one of the most controversial areas of research. The People’s Republic of China has different cultural views [Read More]
Douglas Melton was studying frog eggs at a laboratory in Harvard University when his 6-month-old son Sam was diagnosed with type 1 diabetes. Later, the Melton’s daughter Emma was diagnosed with the same condition. Melton dropped what he was doing and launched efforts to create insulin-producing pancreatic cells in the laboratory. In people with type [Read More]
When Stephen Sykes, 26, from Shepton Mallet in Somerset, United Kingdom, was diagnosed with Hodgkin’s lymphoma, an aggressive type of cancer that did not respond to chemotherapy, a desperate hunt for stem cell donors began. Doctors were unable to find a match even after a worldwide search. Brass bands across the United Kingdom got tested [Read More]
Scientists in the United States made a major breakthrough when they used human cloning to produce embryos in the blastocyst stage. Embryos are a good source of stem cells, which can be used to produce brain, bone, muscle, and other types of specialized cells found in the human body. The methods used by the scientists [Read More]
Stem cell researchers in Japan are using regenerative medicine techniques to find a cure for blindness. A paper was first published in 2006 describing a method to restore sight in mice using stem cells. Despite the initial excitement, more than a decade later, there has been no great progress. A 2015 trial in Japan was [Read More]
A team of researchers at Cedars-Sinai has successfully repaired severe fractures with an innovative method that relies on stem cells. The experiments were conducted in laboratory animals, but if proven effective and safe in humans, could change the way broken bones are treated.
Researchers at the Columbia University Medical Center have developed mini lungs or organoids in the laboratory to help study respiratory diseases. The 3-D structures closely mimic adult-sized lungs and have been created from pluripotent stem cells to serve as models of lung diseases in the laboratory. The findings were reported in Nature Cell Biology.
A team of researchers at the Harvard Stem Cell Institute, working in collaboration with investigators at the Broad Institute of MIT and Harvard, has identified the gene mutation that leads to uncontrolled cell division and tumor formation in some stem cell lines. The Harvard scientists say the findings suggest the need to screen lab-grown stem [Read More]
Researchers have used gene-editing technology and stem cells modified for autonomous regenerative therapy (SMART) to help fight arthritis. Arthritis and many other chronic conditions are associated with inflammation. The idea is to replace arthritic cartilage in the affected joints with stem-cell-produced cartilage and a biological anti-inflammatory agent.
Researchers at the University of British Columbia and the Wellcome Trust Sanger Institute have collaborated to create a novel technique that will allow scientists to observe the interaction of chlamydia with the immune system in humans.
Researchers at the University of Aberdeen in the United Kingdom have identified the stem cells that play a key role in repairing the knee joints. The findings of the team from the Center for Arthritis and Musculoskeletal Health were published in Nature Communications.
Researchers at California’s Gladstone Institutes have used human stem cells to create a neuron that could potentially benefit people with spinal cord injuries. The special type of neurons created by the group is responsible for transmitting signals from the brain to the spinal cord, a process that is essential for movement control.
Scientists at the Clinic for Small Animal Surgery at the University of Zurich have conducted experiments to regenerate damaged spinal discs in dogs. The neurologists hope that the findings will help pave the way for treatment of intervertebral disc disorders in humans.
Stem cell researchers at the Jacobs School of Medicine at the University of Buffalo have reproduced the brain oscillations seen in Parkinson’s disease in a petri dish in the laboratory. This new research will pave the way for new therapies and maybe even a potential cure for Parkinson’s. The findings were published in the online [Read More]
Scientists at the Sanford Burnham Prebys Medical Discovery Institute have uncovered previously unknown stem cell-mediated steps in muscle regeneration. The findings were published in the journal Genes and Development. The new insights into age-related muscle degeneration will also help researchers studying muscular dystrophies.
Scientists are testing a pathbreaking technique to treat heart failure. Using a muscle patch made from the patient’s own stem cells, the researchers have succeeded in repairing damaged hearts with promising results. What is heart failure? When the heart can no longer properly perform its function of pumping blood to the body, it is termed [Read More]
Researchers at The Scripps Research Institute, a not-for-profit biomedical research facility, have developed a new approach to make cells resistant to the HIV virus. In laboratory experiments, the HIV-resistant cells promptly replaced infected cells. The method offers a potential cure for people with HIV. The findings were published in Proceedings of the National Academy of [Read More]
In the laboratory, pluripotent stem cells have embryo-like abilities to develop into different types of tissues found in the human body. However, it is only totipotent stem cells that can develop into embryo-supporting tissues such as the placenta. Since extra-embryonic tissues play an important role in healthy growth and development, scientists at Salk Institute have [Read More]
A study at the Stanford University School of Medicine has revealed that a single protein is key in priming stem cells to respond to injury. Experiments in mice showed that the primer protein helped in quicker recovery from muscle injury. In fact, the skin also healed more rapidly and hair grew back quicker in the [Read More]
Researchers at the University of Portsmouth have collaborated with biologists at the University of Zurich and University of Lyon to discover drugs for brain repair. The team has identified drugs that activate signals to specific types of cells in the adult neurological system. The experiments in mouse models may prove useful in developing treatments of [Read More]