Dr. Mechrefe was raised in Lincoln, R.I., attended the Wheeler School, graduated from Brown University, and then attended the George Washington University School of Medicine where he graduated with High Honors and was inducted into the Alpha Omega Alpha Medical Honor Society.

He then went on to complete an Orthopaedic Residency at Brown University where he was awarded the Haffenreffer Fellow in Medical Sciences Award, and completed an advanced orthopedic trauma fellowship. He then completed a second subspecialty fellowship in foot and ankle reconstruction, making him one of only a few orthopaedic surgeons in New England with this designation.