Bote is a European-trained medical doctor with a PhD in Medicine from Harvard Medical School.

Pig-human chimeras created using stem cells in a key step towards an unlimited source of organs and tissues for regenerative medicine

Regenerative medicine’s ongoing search for new sources of cells, tissues and organs has led to a major leap forward with the development of a human chimeric embryo. A chimera refers to an organism that is genetically made of two different sets of genetic codes. Naturally, this can occur by the fusion of two fertilized eggs [Read More]

3-D printer enables rapid, automated printing of human skin for treatment of burns and other skin conditions

Using a 3-D printer, a group of researchers in Spain has been able to produce functional human skin in record time1. Printing a combination of ‘bioinks’ of human plasma as well as human skin cells, fibroblasts and keratinocytes the group has bio-engineered a skin substitute that can be used for in vitro models for dermal [Read More]

First Human Embryos Genetically Modified Using CRISPR-Cas9 DNA-editing Technique

Developmental biologists of the Karolinska Institute in Stockholm, Sweden have joined only a handful of others in a quest to genetically edit human embryos using CRISPR/Cas-9 technology. The controversial endeavor has underlined ethics talks on modification of human embryonic DNA, also known as ‘germline modification’. The Swedish group has pushed the boundaries by using viable [Read More]

Embryonic stem cells used to regrow nerve connections in patients with spinal cord injuries

Preliminary results have recently been presented on a early-phase clinical trial that aims to treat paralysis as a result of spinal cord injury. Embryonic stem cells differentiated into early nerve cells are used to repair injury to nerves in the spinal cord. The researchers hope to restore muscle function in these recently paralyzed patients. Other [Read More]

Engineering of lung tissue offers a method of creating 3-D lung tissue for studying human disease

One of the challenges in regenerative medicine is the 3-dimensional construction of the complex human tissue that is being attempted to replace. Two-dimensional cultures of functioning cells are a relatively simple laboratory technique for studying cells and disease, yet they are only a simple representation of the true function of an organ. To replicate real [Read More]

Immune System Reboot Using Autologous Stem Cells Proves Effective in the Treatment of Aggressive Multiple Sclerosis

MS stem cell treatment

Recent results from a phase 2 clinical trial using stem cell transplantation have offered new hope for the treatment of aggressive multiple sclerosis. Multiple sclerosis (MS), while not a deadly disease, is known as severely debilitating, slowly deteriorating a patient’s entire nervous system. An aggressive form of MS rapidly results in failure of the nerves [Read More]

Does Our Own Blood Harbor the Fountain of Youth?

fountain of youth

For more than 60 years, we have been expanding the transplantation of organs from the kidneys to the liver, lungs and even the heart. Likewise, the altruistic donation of other bodily tissues and materials has become a mainstay of modern medicine, exemplifying our ability to heal one another. Blood transfusions are used on a daily [Read More]

A New Option For Women Who Can’t Have Babies

woman cant have baby uterus transplant

Infertility, or the inability to reproduce, has major social and psychological consequences for couples who want children. As many as 25 percent of couples experience childlessness following one year of contraceptive-free intercourse. In the majority of cases, factors from both the man and woman contribute to infertility of the pair, but in 30-50 percent of [Read More]

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